NI Margin Comparison

NI Margin Comparison is an interactive analyzer that computes and visualizes four non-inferiority margin scenarios side by side: Dynamic 50%, Dynamic 25%, Traditional 50%, and Traditional 25%. Enter your trial’s event rates and sample sizes to instantly see a forest plot, detailed comparison table, gauge visualizations, and fragility indices for each margin definition.

The tool highlights how the choice between pooled-based (dynamic) and control-based (traditional) margin anchoring can change a trial’s NI conclusion, helping researchers and reviewers critically evaluate margin selection in non-inferiority trial design.